Junior doctors will go into Tuesday’s all-out strike without the explicit backing of any of the profession’s royal colleges amid signs of deep concern among senior consultants that both sides in the dispute need to compromise.

Hospitals across England are finalising plans for dealing with the strike that will be the first in the history of the NHS to affect emergency, paediatric and maternity services. It will run from 8am to 5pm Tuesday and Wednesday. So far, more than 125,000 appointments and operations have been cancelled.

But the scale of the action – and the potentially dangerous impact on patient care – has split the medical profession. In statements over recent days, each of the specialist medical royal colleges have stopped short of endorsing the industrial action and have called for an end to the “damaging stand-off”.